Recent Pubs

M.M. Ouseph; M.E. Kleinman; Q.J. Wang. Vision loss in juvenile neuronal ceroid lipofuscinosis (CLN3 disease). Annals of the New York Academy of Sciences 2016 May
 
B.D. Gelfand; J. Ambati. A Revised Hemodynamic Theory of Age-Related Macular Degeneration. Trends in molecular medicine 2016 Aug
 
R. Yasuma; V. Cicatiello; T. Mizutani; L. Tudisco; Y. Kim; V. Tarallo; S. Bogdanovich; Y. Hirano; N. Kerur; S. Li; T. Yasuma; B.J. Fowler; C.B. Wright; I. Apicella; A. Greco; A. Brunetti; B.K. Ambati; S.B. Helmers; I.E. Lundberg; O. Viklicky; J.H. Leusen; J.S. Verbeek; B.D. Gelfand; A. Bastos-Carvalho; S. De Falco; J. Ambati. Intravenous immune globulin suppresses angiogenesis in mice and humans. Signal transduction and targeted therapy 2016
 
S. Bogdanovich; Y. Kim; T. Mizutani; R. Yasuma; L. Tudisco; V. Cicatiello; A. Bastos-Carvalho; N. Kerur; Y. Hirano; J.Z. Baffi; V. Tarallo; S. Li; T. Yasuma; P. Arpitha; B.J. Fowler; C.B. Wright; I. Apicella; A. Greco; A. Brunetti; M. Ruvo; A. Sandomenico; M. Nozaki; R. Ijima; H. Kaneko; Y. Ogura; H. Terasaki; B.K. Ambati; J.H. Leusen; W.Y. Langdon; M.R. Clark; K.L. Armour; P. Bruhns; J.S. Verbeek; B.D. Gelfand; S. De Falco; J. Ambati. Human IgG1 antibodies suppress angiogenesis in a target-independent manner. Signal transduction and targeted therapy 2016
 
A.K. Berner; M.E. Kleinman. Therapeutic Approaches to Histone Reprogramming in Retinal Degeneration. Advances in experimental medicine and biology 2016
 
T. Mizutani; B.J. Fowler; Y. Kim; R. Yasuma; L.A. Krueger; B.D. Gelfand; J. Ambati. Nucleoside Reverse Transcriptase Inhibitors Suppress Laser-Induced Choroidal Neovascularization in Mice. Investigative ophthalmology & visual science 2015 Nov
 
B.D. Gelfand; C.B. Wright; Y. Kim; T. Yasuma; R. Yasuma; S. Li; B.J. Fowler; A. Bastos-Carvalho; N. Kerur; A. Uittenbogaard; Y. Shan; D. Lou; M.E. Kleinman; W.H. McDonald; G. Núñez; P. Georgel; J.L. Dunaief; J. Ambati. Iron Toxicity in the Retina Requires Alu RNA and the NLRP3 Inflammasome. Cell reports 2015 Jun 23
 
B.D. Gelfand; C.B. Wright; Y. Kim; T. Yasuma; R. Yasuma; S. Li; B.J. Fowler; A. Bastos-Carvalho; N. Kerur; A. Uittenbogaard; Y. Shan; D. Lou; M.E. Kleinman; W.H. McDonald; G. Núñez; P. Georgel; J.L. Dunaief; J. Ambati. Iron Toxicity in the Retina Requires Alu RNA and the NLRP3 Inflammasome. Cell reports 2015 Jun 23
 
B.J. Fowler; B.D. Gelfand; Y. Kim; N. Kerur; V. Tarallo; Y. Hirano; S. Amarnath; D.H. Fowler; M. Radwan; M.T. Young; K. Pittman; P. Kubes; H.K. Agarwal; K. Parang; D.R. Hinton; A. Bastos-Carvalho; S. Li; T. Yasuma; T. Mizutani; R. Yasuma; C. Wright; J. Ambati. Nucleoside reverse transcriptase inhibitors possess intrinsic anti-inflammatory activity. Science (New York, N.Y.) 2014 Nov 21
 
Y. Kim; V. Tarallo; N. Kerur; T. Yasuma; B.D. Gelfand; A. Bastos-Carvalho; Y. Hirano; R. Yasuma; T. Mizutani; B.J. Fowler; S. Li; H. Kaneko; S. Bogdanovich; B.K. Ambati; D.R. Hinton; W.W. Hauswirth; R. Hakem; C. Wright; J. Ambati. DICER1/Alu RNA dysmetabolism induces Caspase-8-mediated cell death in age-related macular degeneration. Proceedings of the National Academy of Sciences of the United States of America 2014 Nov 11
 
Y. Hirano; T. Yasuma; T. Mizutani; B.J. Fowler; V. Tarallo; R. Yasuma; Y. Kim; A. Bastos-Carvalho; N. Kerur; B.D. Gelfand; S. Bogdanovich; S. He; X. Zhang; M. Nozaki; R. Ijima; H. Kaneko; Y. Ogura; H. Terasaki; H. Nagai; I. Haro; G. Núñez; B.K. Ambati; D.R. Hinton; J. Ambati. IL-18 is not therapeutic for neovascular age-related macular degeneration. Nature medicine 2014 Dec
 
N. Kerur; Y. Hirano; V. Tarallo; B.J. Fowler; A. Bastos-Carvalho; T. Yasuma; R. Yasuma; Y. Kim; D.R. Hinton; C.J. Kirschning; B.D. Gelfand; J. Ambati. TLR-independent and P2X7-dependent signaling mediate Alu RNA-induced NLRP3 inflammasome activation in geographic atrophy. Investigative ophthalmology & visual science 2013 Nov 11
 
J. Ambati; J.P. Atkinson; B.D. Gelfand. Immunology of age-related macular degeneration. Nature reviews. Immunology 2013 Jun
 
M.E. Kleinman; J. Ambati. Clocking in on diabetic retinopathy. Diabetes 2013 Jan
 
V. Tarallo; Y. Hirano; B.D. Gelfand; S. Dridi; N. Kerur; Y. Kim; W.G. Cho; H. Kaneko; B.J. Fowler; S. Bogdanovich; R.J. Albuquerque; W.W. Hauswirth; V.A. Chiodo; J.F. Kugel; J.A. Goodrich; S.L. Ponicsan; G. Chaudhuri; M.P. Murphy; J.L. Dunaief; B.K. Ambati; Y. Ogura; J.W. Yoo; D.K. Lee; P. Provost; D.R. Hinton; G. Núñez; J.Z. Baffi; M.E. Kleinman; J. Ambati. DICER1 loss and Alu RNA induce age-related macular degeneration via the NLRP3 inflammasome and MyD88. Cell 2012 May 11
 
V. Tarallo; Y. Hirano; B.D. Gelfand; S. Dridi; N. Kerur; Y. Kim; W.G. Cho; H. Kaneko; B.J. Fowler; S. Bogdanovich; R.J. Albuquerque; W.W. Hauswirth; V.A. Chiodo; J.F. Kugel; J.A. Goodrich; S.L. Ponicsan; G. Chaudhuri; M.P. Murphy; J.L. Dunaief; B.K. Ambati; Y. Ogura; J.W. Yoo; D.K. Lee; P. Provost; D.R. Hinton; G. Núñez; J.Z. Baffi; M.E. Kleinman; J. Ambati. DICER1 loss and Alu RNA induce age-related macular degeneration via the NLRP3 inflammasome and MyD88. Cell 2012 May 11
 
M.E. Kleinman; H. Kaneko; W.G. Cho; S. Dridi; B.J. Fowler; A.D. Blandford; R.J. Albuquerque; Y. Hirano; H. Terasaki; M. Kondo; T. Fujita; B.K. Ambati; V. Tarallo; B.D. Gelfand; S. Bogdanovich; J.Z. Baffi; J. Ambati. Short-interfering RNAs induce retinal degeneration via TLR3 and IRF3. Molecular therapy : the journal of the American Society of Gene Therapy 2012 Jan
 
M.E. Kleinman; H. Kaneko; W.G. Cho; S. Dridi; B.J. Fowler; A.D. Blandford; R.J. Albuquerque; Y. Hirano; H. Terasaki; M. Kondo; T. Fujita; B.K. Ambati; V. Tarallo; B.D. Gelfand; S. Bogdanovich; J.Z. Baffi; J. Ambati. Short-interfering RNAs induce retinal degeneration via TLR3 and IRF3. Molecular therapy : the journal of the American Society of Gene Therapy 2012 Jan
 
S. Dridi; Y. Hirano; V. Tarallo; Y. Kim; B.J. Fowler; B.K. Ambati; S. Bogdanovich; V.A. Chiodo; W.W. Hauswirth; J.F. Kugel; J.A. Goodrich; S.L. Ponicsan; D.R. Hinton; M.E. Kleinman; J.Z. Baffi; B.D. Gelfand; J. Ambati. ERK1/2 activation is a therapeutic target in age-related macular degeneration. Proceedings of the National Academy of Sciences of the United States of America 2012 Aug 21
 
S. Dridi; Y. Hirano; V. Tarallo; Y. Kim; B.J. Fowler; B.K. Ambati; S. Bogdanovich; V.A. Chiodo; W.W. Hauswirth; J.F. Kugel; J.A. Goodrich; S.L. Ponicsan; D.R. Hinton; M.E. Kleinman; J.Z. Baffi; B.D. Gelfand; J. Ambati. ERK1/2 activation is a therapeutic target in age-related macular degeneration. Proceedings of the National Academy of Sciences of the United States of America 2012 Aug 21
 
M.E. Kleinman; J. Ambati. A window to innate neuroimmunity: Toll-like receptor-mediated cell responses in the retina. Advances in experimental medicine and biology 2012
 
H. Kaneko; S. Dridi; V. Tarallo; B.D. Gelfand; B.J. Fowler; W.G. Cho; M.E. Kleinman; S.L. Ponicsan; W.W. Hauswirth; V.A. Chiodo; K. Karikó; J.W. Yoo; D.K. Lee; M. Hadziahmetovic; Y. Song; S. Misra; G. Chaudhuri; F.W. Buaas; R.E. Braun; D.R. Hinton; Q. Zhang; H.E. Grossniklaus; J.M. Provis; M.C. Madigan; A.H. Milam; N.L. Justice; R.J. Albuquerque; A.D. Blandford; S. Bogdanovich; Y. Hirano; J. Witta; E. Fuchs; D.R. Littman; B.K. Ambati; C.M. Rudin; M.M. Chong; P. Provost; J.F. Kugel; J.A. Goodrich; J.L. Dunaief; J.Z. Baffi; J. Ambati. DICER1 deficit induces Alu RNA toxicity in age-related macular degeneration. Nature 2011 Mar 17
 
H. Kaneko; S. Dridi; V. Tarallo; B.D. Gelfand; B.J. Fowler; W.G. Cho; M.E. Kleinman; S.L. Ponicsan; W.W. Hauswirth; V.A. Chiodo; K. Karikó; J.W. Yoo; D.K. Lee; M. Hadziahmetovic; Y. Song; S. Misra; G. Chaudhuri; F.W. Buaas; R.E. Braun; D.R. Hinton; Q. Zhang; H.E. Grossniklaus; J.M. Provis; M.C. Madigan; A.H. Milam; N.L. Justice; R.J. Albuquerque; A.D. Blandford; S. Bogdanovich; Y. Hirano; J. Witta; E. Fuchs; D.R. Littman; B.K. Ambati; C.M. Rudin; M.M. Chong; P. Provost; J.F. Kugel; J.A. Goodrich; J.L. Dunaief; J.Z. Baffi; J. Ambati. DICER1 deficit induces Alu RNA toxicity in age-related macular degeneration. Nature 2011 Mar 17
 
P.A. Pearson; T.L. Comstock; M. Ip; D. Callanan; L.S. Morse; P. Ashton; B. Levy; E.S. Mann; D. Eliott. Fluocinolone acetonide intravitreal implant for diabetic macular edema: a 3-year multicenter, randomized, controlled clinical trial. Ophthalmology 2011 Aug
 
M.E. Kleinman; J.Z. Baffi; J. Ambati. The multifactorial nature of retinal vascular disease. Ophthalmologica. Journal international d'ophtalmologie. International journal of ophthalmology. Zeitschrift fur Augenheilkunde 2010